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Inhibition of Adenosine 3',5'-Monophosphate Accumulation and Lipolysis by Adenosine Analogs in Human Subcutaneous Adipocytes^*

Departments of Medical Chemistry and Clinical Chemistry, University of Helsinki Helsinki, Finland

Address all correspondence and requests for reprints to: Jorma J. Ohisalo, MD., Department of Medical Chemistry, University of Helsinki, Siltavuorenpenger 10 A, SF-00170 Helsinki 17, Finland.

Lipolysis and cAMP accumulation were inhibited by low concentrations of adenosine andits analogs in human sc adipocytes stimulated by 2 µM DL-isoproterenol. The order of potency of the adenosine analogs tested was N⁶-(phen-ylisopropyl)adenosine > 2-chloroadenosine > 5'-N-ethylcarbox-amideadenosine < adenosine > 2',5'-dideoxyadenosine > 2'- deoxyadenosine. Inosine was without effect. No stimulation of cAMP accumulation by 5'-N-ethylcarboxamideadenosine was observed. These results strongly suggest the presence of inhibitory adenosine R_i- and P-sites and the absence of stimulatory R_a-sites in human sc adipocytes.

^* This work was supported by the Nutrition Research Foundation of the Finnish Sugar Co.Ltd., the Paulo Foundation, Hoechst-Fennica Ltd., and the Academy of Finland.

Received January 17, 1983.

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