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Journal of Clinical Endocrinology & Metabolism, Vol 58, 32-35, Copyright © 1984 by Endocrine Society

ARTICLES

Inhibition of adenosine 3',5'-monophosphate accumulation and lipolysis by adenosine analogs in human subcutaneous adipocytes

JJ Ohisalo, S Ranta and IT Huhtaniemi

Lipolysis and cAMP accumulation were inhibited by low concentrations of adenosine and its analogs in human sc adipocytes stimulated by 2 microM DL-isoproterenol. The order of potency of the adenosine analogs tested was N6-(phenylisopropyl)adenosine greater than 2-chloroadenosine greater than 5'-N-ethylcarboxamidoadenosine greater than adenosine greater than 2',5'-dideoxyadenosine greater than 2'-deoxyadenosine. Inosine was without effect. No stimulation of cAMP accumulation by 5'-N- ethylcarboxamidoadenosine was observed. These results strongly suggest the presence of inhibitory adenosine Ri- and P-sites and the absence of stimulatory Ra-sites in human sc adipocytes.


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