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Blood Pressure Response to Thyrotropin-Releasing Hormone in Euthyroid Subjects

Department of Medicine, Division of Endocrinology and Metabolism, Hahnemann University School of Medicine Philadelphia, Pennsylvania 19012

Address requests for reprints to: Leslie I. Rose, M.D., Division of Endocrinology and Metabolism, Hahnemann University School of Medicine, 230 North Broad Street, Philadelphia, Pennsylvania 19102.

The iv administration of TRH has been associated with side effects, such as nausea, flushing, and urinary urgency. However, few reports mention changes in blood pressure. This study defines the mean and range of the blood pressure responses in 70 euthyroid patients subjected to iv administered TRH. The mean increase was 21.0 ± 1.4 mm Hg for systolic and 13.9 ± 1.0 mm Hg for diastolic blood pressure; however, individual peak values increased as much as 56 and 42 mm Hg, respectively. Thus, the hemodynamic response to iv administered TRH can be quite severe in some subjects, and caution is suggested in selecting patients for testing.

Received May 13, 1983.

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