help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schulte, H. M.
Right arrow Articles by Loriaux, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schulte, H. M.
Right arrow Articles by Loriaux, D. L.

Journal of Clinical Endocrinology & Metabolism, Vol 58, 192-196, Copyright © 1984 by Endocrine Society

ARTICLES

Corticotropin-releasing factor: pharmacokinetics in man

HM Schulte, GP Chrousos, JD Booth, EH Oldfield, PW Gold, GB Cutler Jr and DL Loriaux

Corticotropin-releasing factor (CRF), a 41-amino acid peptide isolated and sequenced from ovine hypothalami, has potential clinical application as a provocative test of the hypothalamic-pituitary-adrenal axis. To define its pharmacokinetic parameters in man, we measured the MCR and plasma half-life of immunoreactive CRF (IR-CRF) by the pulse injection and continuous infusion methods. Synthetic ovine CRF was given to 12 normal men as a bolus injection (1 microgram/kg; n = 6) or as a continuous infusion (0.51 +/- 0.05 micrograms/kg X h; n = 6) over 8 h. The disappearance curve of IR-CRF from plasma was biexponential. The plasma half-life of IR-CRF was 11.6 +/- 1.5 min (mean +/- SE) for the fast component and 73 +/- 8 min for the slow component. The MCR using the pulse injection technique was 95 +/- 11 liters/m2 X day, and the volume of distribution was 6.2 +/- 0.5 liters. Continuous infusion of CRF gave approximately the same MCR (88 +/- 7 liters/m2 X day). A small percentage of IR-CRF (approximately 0.03%) was found in the urine at the end of the continuous infusion. The relatively low MCR of CRF may explain its prolonged biological action in primates and man.


This article has been cited by other articles:


Home page
 Arch Gen PsychiatryHome page
R. C. Daly, T.-P. Su, P. J. Schmidt, D. Pickar, D. L. Murphy, and D. R. Rubinow
Cerebrospinal Fluid and Behavioral Changes After Methyltestosterone Administration: Preliminary Findings
Arch Gen Psychiatry, February 1, 2001; 58(2): 172 - 177.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. A. Yanovski, S. Z. Yanovski, A. J. Boyle, P. W. Gold, K. N. Sovik, N. G. Sebring, and B. Drinkard
Hypothalamic-Pituitary-Adrenal Axis Activity during Exercise in African American and Caucasian Women
J. Clin. Endocrinol. Metab., August 1, 2000; 85(8): 2660 - 2663.
[Abstract] [Full Text]

Home page
 Ann. N. Y. Acad. Sci.Home page
M. B. HENNESSY, H. N. DAVIS, A. E. McCREA, A. T. HARVEY, and M. T. WILLIAMS
Short- and Long-term Consequences of Corticotropin-releasing Factor in Early Development
Ann. N.Y. Acad. Sci., January 1, 1999; 897(1): 76 - 91.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1984 by The Endocrine Society