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Anti-receptor Antibodies Mimic the Effect of Insulin to Down-Regulate Insulin Receptors in Cultured Human Lymphoblastoid (IM-9) Cells

Diabetes Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, National Institutes of Health Bethesda, Maryland 20205

Address all correspondence and requests for reprints to: Simeon I. Taylor, M.D., Ph.D., National Institutes of Health, Diabetes Branch, National Institute of Arthritis, Diabetes, Digestive, and Kidney Diseases, Building 10, Room 8S-243, Bethesda, Maryland 20205.

Autoantibodies directed against the insulin receptor mimicked the effect of insulin to down-regulate insulin receptors in IM-9 cells. This down-regulation occurred at 37 C, but not at 15 or 22 C. As with insulin itself, antireceptor antibodies caused down-regulation by accelerating the rate of receptor degradation. Down-regulation induced by antireceptor antibody may play a role in desensitizing target cells to the effects of insulin.

Received June 20, 1983.

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