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Journal of Clinical Endocrinology & Metabolism, Vol 57, 1311-1313, Copyright © 1983 by Endocrine Society

ARTICLES

Insulin regulates placental lactogen and estradiol secretion by cultured human term trophoblast

Z Hochberg, R Perlman, JM Brandes and A Benderli

We have described a human term trophoblast cell culture system which synthesizes hormones de novo from their precursors. In the present report we utilized this monolayer system to show that insulin produced a dose-dependent stimulation of hPL secretion, with a significant effect at 10(-10) M insulin. At 10(-9) M concentration, insulin also inhibited estradiol secretion by the cultured trophoblast. We conclude that insulin regulates secretion of estradiol and placental lactogen by cultured human term trophoblast.




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Copyright © 1983 by The Endocrine Society