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INSULIN REGULATES PLACENTAL LACTOGEN AND ESTRADIOL SECRETION BY CULTURED HUMAN TERM TROPHOBLAST

Pediatric Endocrine Unit, Departments of Pediatrics and Obstetrics, Rambam Medical Center, and Faculty of Medicine, Technion-Israel Institute of Technology Haifa, Israel

Address correspondence to: Dr.Zeev Hochberg, Endocrine Laboratory, Rambam Medical Center, Haifa 35254, Israel.

We have described a human term trophoblast cell culture system which synthesizes hormones de novo from their precursors. In the present report we utilized this monolayer system to show that insulin produced a dose-dependent stimulation of hPL secretion, with a significant effect at 10^–10 M insulin. At 10^–9 M concentration, insulin also inhibited estradiol secretion by the cultured trophoblast. We conclude that insulin regulates secretion of estradiol and placental lactogen by cultured human term trophoblast.

This work was presented in part at the annual meeting of the Israel Diabetes Association, Haifa, January1983.

Received April 29, 1983.