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Journal of Clinical Endocrinology & Metabolism Vol. 57, No. 6 1308-1310
doi:10.1210/jcem-57-6-1308
Copyright © 1983 by the Endocrine Society.
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SPECIFIC HIGH-AFFINITY RECEPTORS FOR 1,25-DIHYDROXYVITAMIN D3 IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS: PRESENCE IN MONOCYTES AND INDUCTION IN T LYMPHOCYTES FOLLOWING ACTIVATION

ASHOK. K BHALLA*, EDWARD P AMENTO*, THOMAS L CLEMENS**, MICHAEL F HOLICK** and STEPHEN M KRANE*

* Department of Medicine, Harvard Medical School and the Medical Services Arthritis units Massachusetts General Hospital Boston, MA 02114.
** Department of Medicine, Harvard Medical School and the Medical Services Endocrine units Massachusetts General Hospital Boston, MA 02114.

Human peripheral blood monocytes have high affinity binding sites for 1,25-(OH)2D3 (Kd 0.14 nM, sedimentation coefficient 3.7S). Resting human peripheral blood T lymphocytes, however, do not have a demonstrable 1,25-(OH)2D3 receptor. After activation with phytohemagglutinin the T cells exhibit the receptor within 24 h, and this expression is blocked by cycloheximide. The receptor in activated T lymphocytes has a sedimentation coefficient of 3.7S and a high affinity (Kd 0.10 nM) for the ligand.

Received September 1, 1983.




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