| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Medicine, Tokyo Womens Medical College Tokyo
* Second Department of Medicine, Tohoku University School of Medicine Sendai
The concentrations of immunoreactive corticotropin-releasing factor (I-CRF) in human cerebrospinal fluid (CSF) were measured utilizing immunoaffinity chromatography and RIA in patients with no endocrine disease, patients with Cushings disease, Nelsons syndrome, Sheehans syndrome, Addisons disease and steroid treated patients. On high performance liquid chromatography, the elution profile and retention time of I-CRF in CSF were not identical with ovine CRF. I-CRF concentrations in CSF from patients with Cushings disease and Sheehans syndrome were lower than those from normal subjects, however those from patients with Nelsons syndrome and Addisons disease were within the normal range. I-CRF cencentrations in CSF from patients with Cushings disease returned to normal levels 2-9 months after pituitary adenomectomy. These results suggest that CSF I-CRF concentrations are reduced by increased plasma corticosteroid levels.
Received July 22, 1983.
This article has been cited by other articles:
![]() |
H. E. Gwirtsman, W. H. Kaye, D. T. George, D. C. Jimerson, M. H. Ebert, and P. W. Gold Central and Peripheral ACTH and Cortisol Levels in Anorexia Nervosa and Bulimia Arch Gen Psychiatry, January 1, 1989; 46(1): 61 - 69. [Abstract] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |