This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by PONTIROLI, A. E. Articles by POZZA, G. Search for Related Content PubMed PubMed Citation Articles by PONTIROLI, A. E. Articles by POZZA, G.

Study of Hypoglycemic Patients by the Glucose Clamp Technique Using the Artificial Pancreas

Clinica Medica VIII, Universitá di Milano, and Fondazione San Romanello del Monte Tabor, Ospedale San Raffaele Milano, Italy

Address requests for reprints to: Dr. A. E. Pontiroli, Ospedale San Raffaele, Via Olgettina 60, 20132 Milano, Italy.

Using the artificial pancreas, blood glucose levels were maintained at 80 mg/dl in nine hypoglycemic patients (four with histologically proven insulinomas and five with nontumoral hypoglycemia) and in four normal subjects during a 24-h fast. The amount of glucose used, serum insulin levels, and glucose clearance were higher in patients with nontumoral hypoglycemia than in normal subjects and highest in the patients with an insulinoma. Surgical or pharmacological treatment resulted in normalization of all parameters. In contrast to the 72-h fast, the 24-h glucose clamp technique allowed the study of hypoglycemic patients without inducing hazardous hypoglycemia.

Received October 24, 1982.

This article has been cited by other articles:

				J. H. REYNOLDS, N. I. KAMINSKY, D. S. SCHADE, and R. P. EATON Use of a Computerized Glucose Clamp Technique to Diagnose an Insulinoma Ann Intern Med, November 1, 1984; 101(5): 648 - 649. [Abstract] [PDF]