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Journal of Clinical Endocrinology & Metabolism Vol. 57, No. 6 1159-1163
doi:10.1210/jcem-57-6-1159
Copyright © 1983 by the Endocrine Society.
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Different Rebound Rise in Plasma Prolactin during the Postdopamine Infusion Phase in Puerperal Women and Patients with Pathological Hyperprolactinemia

A. R. GENAZZANI, F. CAVAGNINI, G. B. PICOTTI, E. GHIGO, V. DE LEO, M. D. GALVA, C. MARASCHINI and E. E. MULLER

Chair of Obstetrics and Gynecology University of Modena, First Medical Clinic University of Milan, Chair of Endocrinology University of Turin, Chair of Obstetric Pathology University of Siena, and Department of Pharmacology, Chemotherapy, and Toxicology, University of Milan Milan, Italy

Address all correspondence and requests for reprints to: Dr. Eugenio E. Muller, Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy.

Dopamine infused at a rate of 4 µg/kg·min for 120 min induced at the end of the infusion period a clear-cut and similar suppression of circulating PRL levels in normal and puerperal women as well as in patients with hyperprolactinemia either due to a tumor or of unknown etiology. At the discontinuation of the infusion there was a marked PRL rebound above baseline levels in normal subjects and a rapid return to basal levels in subjects with pathological hyperprolactinemia. In contrast, there was no increase in plasma PRL in puerperal women, in whom PRL levels remained suppressed during the whole postinfusion period. The reason(s) for this pattern in puerperal women is presently unknown, although previous estrogen loading of the lactotropes during pregnancy may be involved.

Received January 24, 1983.







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Copyright © 1983 by The Endocrine Society