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Effect of Estrogen on Vitamin D Metabolism in Tall Girls^*

Department of Pediatrics, University of Bergen Bergen, Norway

Address requests for reprints to: Dagfinn Aarskog, M.D., Department of Pediatrics, University of Bergen, N-5016, Bergen, Norway.

To determine the effect of estrogen on vitamin D metabolism in pubertal girls, we studied 16 tall girls treated with a daily dose of 4–8 mg estradiol valerate to curtail excessive adult height. In all but one girl the plasma concentration of 1,25-dihydroxyvitamin D (1,25-(OH)₂D) increased to values significantly higher than the corresponding pretreatment value (P < 0.0005). The ratio of 24,25-dihydroxyvitamin D (24,25-(OH)₂D) to 25-hydroxyvitamin D decreased in all girls (P < 0.0005). The vitamin D binding protein (DBP) also increased significantly after estrogen (P <0.025), and there was a significant positive correlation between the plasma concentration of 1,25-(OH)₂D and DBP (r = 0.66; P < 0.0005). The free fraction of 1,25-(OH)₂D remained unchanged after estrogen. It appears that estrogen treatment increases the plasma concentration of 1,25-(OH)₂D. The effect might be explained by the concomitant increase in DBP and/or by estrogen stimulation of renal lahydroxylase.

^* This work was supported by the Norwegian Research Council for Science and the Humanities, the Norwegian Cancer Society, and the Nordisk Insulin Foundation.

Received March 16, 1983.

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