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Cholinergic Receptor Control Mechanisms for L-Dopa, Apomorphine, and Clonidine-Induced Growth Hormone Secretion in Man^*

Insitute of Medical Clinic, University of Sassari, Chair of Endocrinology, University of Sassari Sassari (Sardinia), Italy
Chair of Endocrinology University of Florence Florence, Italy

Address correspondence and requests for reprints to: Dr. Giuseppe Delitala, Chair of Endocrinology, University of Sassari, Viale San Pietro n. 12, 07100 Sassari (Sardinia), Italy.

The effect of pirenzepine, an anticholinergic agent, on GH release induced by L-dopa (500 mg po), apomorphine (0.75 mg sc), and clonidine (0.150 mg iv) administration was studied in a group of normal men. Pirenzepine, a cholinergic muscarinic antagonist, completely blocked the GH rise induced by dopamine- and adreno-receptor stimulation. In contrast, the PRL-inhibiting action of L-dopa was not modified by the cholinergic antagonist. The data suggest that acetylcholine and its receptors are important regulators of the neurosecretory mechanisms that control GH secretion in man.

^* This work was supported by a Ministero della Pubblica Istruzione grant (to G.D.).

Received March 29, 1983.

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