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Journal of Clinical Endocrinology & Metabolism Vol. 57, No. 2 428-431
doi:10.1210/jcem-57-2-428
Copyright © 1983 by the Endocrine Society.
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The Extrathyroidal Conversion of 3,5,3'- Triiodothyronine to 3,5-Diiodothyronine in Patients with Liver Cirrhosis*

J. FABER, C. KIRKEGAARD, H. FRANCIS THOMSEN, I. B. LUMHOLTZ, K. SIERSBÆK-NIELSEN and T. FRIIS

Department of Internal Medicine E and B, and Clinical Chemistry, Frederiksberg Hospital 2000 F, Copenhagen, Denmark

Address all correspondence and requests for reprints to: J. Faber, M.D., Department of Internal Medicine E, Frederiksberg Hospital, DK-2000 F, Copenhagen, Denmark.

Simultaneous kinetic studies of 3,5-diiodothyronine (3,5-T2) and T3 were performed in 8 patients with biopsy proven cirrhosis and in 15 healthy subjects using the single injection, noncompartmental approach. The following T3 kinetic data were obtained in patients with cirrhosis and normal subjects (mean ± SD): serum T3 (nmol/liter) 1.27 ± 0.30 vs. 1.79 ± 0.28 (P < 0.001); MCR [liters x day1 x (70 kg)-1] 22.9 ± 5.3 vs. 26.7 ± 4.4 (P < 0.10); production rate [nmol x day-1 x (70 kg)-1] 29.0 ± 9.6 vs. 47.7 ± 9.0 (P < 0.001).

In patients with cirrhosis serum 3,5-T2 levels were reduced to 58 ± 38% of those found in normal subjects (P < 0.02). The MCR was unaffected, 125 ± 85%, whereas the production rate was reduced to 57 ± 26% (P < 0.005). The conversion rate from T3 to 3,5-T2 was unaltered, 96 ± 34% of that found in normals.

It is concluded that reduced serum levels of 3,5-T2 in cirrhosis are due to a diminished amount of substrate, T3, and not to decreased 3'-deiodination of T3 or to an increase clearance of 3,5-T2.

* This work was supported by The Danish Hospital Foundation for Medical Research, Region of Copenhagen, Faroe Islands, and Greenland; The Danish Medical Research Council; and the Nordic Insulin Foundation.

Received September 3, 1982.






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Copyright © 1983 by The Endocrine Society