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Journal of Clinical Endocrinology & Metabolism Vol. 57, No. 2 425-427
doi:10.1210/jcem-57-2-425
Copyright © 1983 by the Endocrine Society.
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Evidence of Receptors for Thyrotropin-Releasing Hormone in Human Prolactin- Secreting Adenomas*

M. LE DAFNIET, A. M. BRANDI, D. BRESSION, T. RACADOT and F. PEILLON

INSERM U 223, Physiopathobgie de I’hypophyse et ERA CNRS 484, Faculté de Médecine Pitié- Salpétriére 75634 Paris Cedex 13, France

Address requests for reprints to: M. Le Dafniet, INSERM U 223, Faculté de Médecine Pitié-Salpétriére, 105 Boulevard de l’Hopital, 75634 Paris Cedex 13, France.

Specific receptors for TRH were demonstrated on cellular membranes from 8 out of 10 human PRL-secreting adenomas. One binding site was characterized. The mean (±SD) value for the dissociation constant (Kd) from 8 adenomas was 68 ± 7 nM. The maximal number of binding sites varied from 1 adenoma to another (from 50–1200 fmol/mg protein). In 7 ofthe 8 patients, there was little or no in vivo plasma PRL response to TRH although receptors for TRH were present on their tumors. It is thus suggested that in vivo absence of stimulatory effect of TRH in human PRL-secreting adenomas is not due to the absence of TRH receptors.

* This work was supported by INSERM, CNRS (ATP 033815), and Conseil Scientifique de la Faculté de Médecine Pitié-Salpétriére.

Received October 22, 1982.




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M. Yamada, K. Hashimoto, T. Satoh, N. Shibusawa, H. Kohga, Y. Ozawa, S. Yamada, and M. Mori
A Novel Transcript for the Thyrotropin-Releasing Hormone Receptor in Human Pituitary and Pituitary Tumors
J. Clin. Endocrinol. Metab., December 1, 1997; 82(12): 4224 - 4228.
[Abstract] [Full Text] [PDF]


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Copyright © 1983 by The Endocrine Society