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Sequential Serum Measurements of Thyrotropin Binding Inhibitor Immunoglobulin G in Transient Familial Neonatal Hypothyroidism

Departments of Pediatrics (M.I., M.S., T.O., H.H.) and Internal Medicine (K.A., Y.I.), School of Medicine, Keio University, and Ito Thyroid Clinic and Hospital (N.M., K.I.) Tokyo, Japan

Address all correspondence and requests for reprints to: Mikiro Iseki, Department of Pediatrics, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160, Japan.

Infants with transient neonatal hypothyroidism, in whom TSH binding inhibitor immunoglobulin G (IgG) (TBII) were sequentially measured, are described. Their mother had been taking thyroid replacement for hypothyroidism due to nongoitrous autoimmune thyroiditis. IgGs inhibiting TSH binding were detected in maternal sera by radioreceptor assay. These IgGs also inhibited the adenylate cyclase response to TSH in human thyroid membranes. Three infants had frank hypothyroidismhypothyroidism immediately after birth, and TBII were detected in two of them. In the two surviving infants, hypothyroidism was transient and improved when TBII disappeared from their sera. The profile of TBII in one patient corresponded to the IgG disappearance curve. These findings suggest that the transient neonatal hypothyroidism reported was caused by transplacental transfer of TBII. J Clin Endocrinol Metab 57: 384, 1983)

Received September 15, 1982.

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