help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Henson, L. C.
Right arrow Articles by Heber, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Henson, L. C.
Right arrow Articles by Heber, D.

Journal of Clinical Endocrinology & Metabolism, Vol 57, 316-319, Copyright © 1983 by Endocrine Society

ARTICLES

Whole body protein breakdown rates and hormonal adaptation in fasted obese subjects

LC Henson and D Heber

Fasting is known to result in marked decreases in urinary urea nitrogen excretion over a 7-day period. In the present studies, changes in whole body protein breakdown rates and in the circulating levels of a number of hormones involved in protein anabolism and catabolism were systematically studied in nine obese subjects after 12 h and after 7 days of fasting. Whole body protein breakdown rates, measured with a primed continuous infusion of L-[U-14C]lysine, were decreased after 7 days of fasting (1.54 +/- 0.12 g/kg . day) compared to those after 12 h of fasting (1.96 +/- 0.10 g/kg . day). Plasma insulin decreased and glucagon increased after 7 days of fasting, resulting in an increased glucagon to insulin molar ratio. Plasma cortisol, urinary free cortisol excretion plasma rT3 levels, and branched chain amino acid levels increased after 7 days of fasting. Serum lysine levels, used for the calculations of whole body protein breakdown rates, were not changed. We conclude: 1) decreased whole body protein breakdown contributes significantly to the decreased nitrogen excretion observed with fasting in obese subjects; and 2) a decrease in circulating levels of free T3 may lead to this adaptive decrease in protein breakdown in fasted obese subjects, since the other hormones measured either did not change or changed in a catabolic direction.


This article has been cited by other articles:


Home page
 Ann. N. Y. Acad. Sci.Home page
K. LIN-SU, S. NIMKARN, and M. I. NEW
Congenital Adrenal Hyperplasia in Adolescents: Diagnosis and Management
Ann. N.Y. Acad. Sci., June 1, 2008; 1135(1): 95 - 98.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
H. Nørrelund, K. S. Nair, J. O. L. Jørgensen, J. S. Christiansen, and N. Møller
The Protein-Retaining Effects of Growth Hormone During Fasting Involve Inhibition of Muscle-Protein Breakdown
Diabetes, January 1, 2001; 50(1): 96 - 104.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. A. Yanovski, S. Z. Yanovski, P. W. Gold, and G. P. Chrousos
Differences in Corticotropin-Releasing Hormone-Stimulated Adrenocorticotropin and Cortisol before and after Weight Loss
J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1874 - 1878.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1983 by The Endocrine Society