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Somatomedins in Adolescence: A Cross-Sectional Study of the Effect of Puberty on Plasma Insulin-Like Growth Factor I and II Levels^*

Department of Pediatrics, Stanford School of Medicine Stanford, California 94305
Department of Pediatrics, Kaiser-Per manente Medical Center (C.J.W.) San Francisco, California 94115
Department of Pediatrics, San Francisco General Hospital (R.C.B.) San Francisco, California 94110

Address requests for reprints to: Dr. Darrell M. Wilson, S322 Department of Pediatrics, Stanford University Medical Center, Stanford, California 94305.

To explore the effect of puberty on the somato-medins (SMs), a group of insulin-like peptides which mediate the action of GH on skeletal tissue, we measured SM-C/insulin-like growth factor-I (SM-C/IGF-I) and IGF-II by specific RIAs in 110 adolescents between the ages of 10 and 18 yr. All subjects were in good health and between the 5th and 95th percentiles for height.

In both females and males, SM-C/IGF-I levels rose during puberty to a peak approximately 3-fold higher than the average adult level. The rise in SM-C/IGF-I levels corresponded better with the Tanner stage of the adolescents than with their chronological age. IGF-II levels did not rise during puberty and were slightly below adult levels.

The dramatic rise in SM-C/IGF-I levels during puberty suggests a role for this SM peptide in the adolescent growth spurt. Furthermore, these data indicate that proper interpretation of SM-C/IGF-I levels during adolescence must include a knowledge of the patient's pubertal development.

^* This work was supported in part by the Robert Wood Johnson Foundation and NIH Grants AM-07217–5, AM-21058, and AM-24085.

Received January 5, 1982.

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