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Journal of Clinical Endocrinology & Metabolism, Vol 57, 197-199, Copyright © 1983 by Endocrine Society

ARTICLES

Normal plasma gonadotropin response to gonadotropin-releasing hormone after diethylstilbestrol priming in transsexual women

M Wiesen and W Futterweit

Plasma LH and FSH responses to GnRH (100 micrograms, iv) were measured in four female transsexuals with normal ovulatory menstrual cycles before and after the administration of 2.0 mg diethylstilbestrol (DES) daily for 7 days. One normal ovulatory woman was also studied in the early follicular phase of the menstrual cycle. No difference was found in the augmented response of the four female transsexuals to GnRH after DES priming from that of the normal adult female. The augmented response to GnRH found in the female transsexuals after DES treatment provides evidence that hypothalamic-pituitary feedback control is normal in the female transsexuals studied.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1983 by The Endocrine Society