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Journal of Clinical Endocrinology & Metabolism, Vol 56, 1332-1334, Copyright © 1983 by Endocrine Society

ARTICLES

Relaxin stimulates collagenase and plasminogen activator secretion by dispersed human amnion and chorion cells in vitro

ES Koay, CK Too, FC Greenwood and GD Bryant-Greenwood

Dispersed cells from human amnion and chorion were cultured with and without relaxin. The addition of this hormone caused an increased secretion of both collagenase and plasminogen activator into the culture medium over a 32 h period, but had no effect on proteoglycanase or beta-glucuronidase secretion. The increase in plasminogen activator was dose-related to the amount of relaxin added in vitro. The results show that the fetal membranes are a novel target tissue for relaxin in the human, and suggest that relaxin in vivo may cause a similar release of collagenolytic enzymes, leading to the weakening and eventual rupture of the fetal membranes.


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Copyright © 1983 by The Endocrine Society