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Blunted Plasma Cyclic Adenosine Monophosphate Response to Isoproterenol in Pseudohypoparathyroidism^*

Medical and Research Services, Wadsworth Veterans Administration Hospital, Los Angeles, California 90073 and Sepulveda Veterans Administration Hospital, Sepulveda, California 91343; and Department of Medicine, University of California School of Medicine, Los Angeles, California 90024

Address correspondence and requests for reprints to: Harold E. Carlson, M.D., Endocrinology Section, Harry Truman Veterans Administration Hospital, 800 Stadium Road, Columbia, Missouri 65201.

Plasma cAMP, serum glucose, and cardiovascular responses to isoproterenol infusion were examined in seven normal subjects and seven patients with pseudohypoparathyroidism (PHP), type I (three with deficiency of the hormone receptor-cyclase coupling protein (N-protein) and four who were N-protein replete). Although plasma cAMP responses were blunted in both subgroups of PHP patients, the cardiovascular and glucose responses to isoproterenol were normal. We conclude that the blunted plasma cAMP response to isoproterenol in PHP does not depend on deficient N-protein coupling of adenylate cyclase to the β-adrenergic receptor and that the cardiovascular and glucose responses to isoproterenol are not reflected in changes in plasma cAMP. (J Clin Endocrinol Metab 56:1323,1983)

^* This work was supported by funds from the Research Service of the VA and NIH Clinical Research Center Grant DRR-00865.

Received July 8, 1982.

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