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Journal of Clinical Endocrinology & Metabolism Vol. 56, No. 6 1301-1305
doi:10.1210/jcem-56-6-1301
Copyright © 1983 by the Endocrine Society.
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The Presence of Myoglobin in Human Thyroid Tissue

Kazuo Miyoshi, Hisaomi Kawai, Masaru Iwasa, Kanae Kusaka, Masafumi Yonezawa and Yoshimasa Shishiba

The First Department of Internal Medicine, School of Medicine, the University of Tokushima, Tokushima and Okinaka Memorial Institute for Medical Research, Akasaka, Tokyo

Address correspondence and requests for reprints to: Yoshimasa Shishiba, M.D., Okinaka Memorial Institute for Medical Research, Toranomon, 2-2-2, Minato-ku, Tokyo 105, Japan.

In the present study we sought to determine the presence of myoglobin in human thyroid tissue. When reacted with antihuman myoglobin antibody on the Ouchterlony plate, homogenates of human thyroid tissue formed a precipitation line. When the human thyroid extract was included in human myoglobin RIA, the dilution curve of thyroid extract was parallel to the standard curve of myoglobin. When the myoglobin immunoreactivity in thyroid extract was fractionated with Sephadex G 75 column, the immunoreactivity was eluted in a peak identical with authentic myoglobin. The position of the peak was different from that of thyroglobulin. Myoglobin concentration in thyroid tissue was estimated to be 0.7–110 mg/g wet wt, being about 1/6000 to 1/40 of that in skeletal muscle. Histochemical studies demonstrated the presence of myoglobin immunoreactivity in thyroid tissue, especially in the apical border of thyroid epithelial cells, implying a functional role in iodinating process or exocytotic-endocytotic process. (J Clin Endocrinol Metab 56: 1301,1983)

Received May 4, 1982.






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Copyright © 1983 by The Endocrine Society