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Journal of Clinical Endocrinology & Metabolism, Vol 56, 1094-1099, Copyright © 1983 by Endocrine Society

ARTICLES

Effects of cyproheptadine, reserpine, and synthetic corticotropin- releasing factor on pituitary glands from patients with Cushing's disease

T Suda, F Tozawa, T Mouri, A Sasaki, T Shibasaki, H Demura and K Shizume

Direct effects of cyproheptadine, reserpine, synthetic ovine corticotropin-releasing factor (CRF), dexamethasone, and lysine-8- vasopressin (LVP) on the secretion of immunoreactive ACTH and beta- endorphin from the adenoma and the nonadenomatous tissue of patients with Cushing's disease were examined using a superfusion system. Cyproheptadine and reserpine (10(-9)-10(-7) M of each) suppressed immunoreactive ACTH and beta-endorphin secretion from both tissues. CRF (10(10)-10(7) M) stimulated the secretion of both peptides from the nonadenomatous tissue, but only a high dose of CRF could stimulate the secretion of these peptides from some adenomas. Such CRF-induced secretion was partially suppressed by dexamethasone. LVP (10(-9)-10(-7) M) stimulated peptide secretion from both types of tissue. These results suggest direct inhibitory effects of cyproheptadine and reserpine on the secretion of these peptides from the pituitary of patients with Cushing's disease, a different stimulatory mechanism of LVP from that of CRF in these tissues, and low sensitivity of the adenoma to CRF.


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