help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Journal of Clinical Endocrinology & Metabolism Vol. 56, No. 5 936-939
doi:10.1210/jcem-56-5-936
Copyright © 1983 by the Endocrine Society.
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mcdermott, M. T.
Right arrow Articles by Hofeldt, F. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mcdermott, M. T.
Right arrow Articles by Hofeldt, F. D.

Reduced Bone Mineral Content in Totally Thyroidectomized Patients: Possible Effect of Calcitonin Deficiency*

Michael T. Mcdermott, Gerald S. Kidd, Peter Blue, Victor Ghaed and Fred D. Hofeldt

Endocrinology Service, Department of Medicine, and Nuclear Medicine Service, Department of Radiology, Fitzsimons Army Medical Center, Aurora, Colorado 8004

Address requests for reprints to Michael T. McDermott, M.D., M.A.J., M.C., Endocrinology Service, Department of Medicine, Fitzsimons Army Medical Center, Aurora, Colorado 80045.

To further investigate the relationship between calcitonin deficiency and osteoporosis, we have measured bone mineral content (BMC) by single photon absorptiometry in patients made iatrogenically calcitonin deficient by prior total thyroidectomy for thyroid cancer. Compared to sex-, age-, height-, and weight-matched normal controls, male patients had a significantly lower mean BMC at the midradius (1.162 ± 0.02 vs. 1.301 ± 0.05 g/cm; P < 0.02) and the distal radius (1.180 ± 0.04 vs. 1.338 ± 0.04 g/cm; P < 0.01). Female patients also had a significantly lower BMC at the midradius compared to those of a similarly matched group of normal controls and a group of patients on L-T4 suppression for nodular goiters (0.791 ± 0.04 vs. 0.896 ± 0.05 vs. 0.891 ± 0.03 g/cm; P < 0.025). We conclude that calcitonin deficiency from surgical thyroidectomy is associated with significant decreases in bone mineral content in both sexes. This lends further support to the concept that calcitonin deficiency may be an important causative factor in the development of osteoporosis. (J Clin Endocrinol Metab 56 936,1983)

* The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or of the Department of Defense.

Received August 31, 1982.




This article has been cited by other articles:


Home page
Arch SurgHome page
S. Noguchi, N. Murakami, H. Yamashita, M. Toda, and H. Kawamoto
Papillary Thyroid Carcinoma: Modified Radical Neck Dissection Improves Prognosis
Arch Surg, March 1, 1998; 133(3): 276 - 280.
[Abstract] [Full Text] [PDF]


Home page
JAMAHome page
A. W. C. Kung and K. K. Pun
Bone Mineral Density in Premenopausal Women Receiving Long-term Physiological Doses of Levothyroxine
JAMA, May 22, 1991; 265(20): 2688 - 2691.
[Abstract] [PDF]


Home page
ANN INTERN MEDHome page
G. D. GRAHAM and K. D. BURMAN
Radioiodine Treatment of Graves' Disease: An Assessment of Its Potential Risks
Ann Intern Med, December 1, 1986; 105(6): 900 - 905.
[Abstract] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1983 by The Endocrine Society