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Journal of Clinical Endocrinology & Metabolism Vol. 56, No. 5 889-892
doi:10.1210/jcem-56-5-889
Copyright © 1983 by the Endocrine Society.
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Effect of Dopamine on Gonadotropin-Releasing Hormone-Induced Gonadotropin Secretion in Postmenopausal Women*

Jon J. Pehrson, William L. Jaffee and Judith L. Vaitukaitis

Department of Medicine, Boston University School of Medicine, and the Section of Endocrinology and Metabolism, Thorndike Memorial Laboratory, Boston City Hospital, Boston, Massachusetts 02118

Address requests for reprints to Dr. Jon Pehrson, Thorndike 102, Boston City Hospital, 818 Harrison Avenue, Boston, Massachusetts 02118.

Five healthy women who had previously undergone spontaneous menopause and had not received exogenous estrogens were studied with infusions of synthetic GnRH and dopamine to ascertain the site of dopaminergic modulation of pituitary gonadotropin secretion. Infusion of dopamine at 4 µg/kg·min for 5 h induced a significant decrease in circulating LH concentrations, but not those of FSH. LH levels returned to baseline concentrations during the postinfusion period. Infusion with synthetic GnRH at 10 µg/h for 5 h induced a biphasic change in circulating gonadotropin levels. When dopamine and GnRH were simultaneously infused for 5 h, FSH and LH responses were not statistically different from those observed when GnRH was infused alone. We conclude that in normal postmenopausal women, dopamine modulates pituitary gonadotropin secretion by affecting GnRH-secreting neurons in the median eminence and possibly at other hypothalamic sites. (JClin Endocrinol Metab 56: 889, 1983)

* This work was supported in part by USPHS Grants RR-533 and T32-AM-07201.

Received August 31, 1982.






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Copyright © 1983 by The Endocrine Society