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Journal of Clinical Endocrinology & Metabolism Vol. 56, No. 5 871-875
doi:10.1210/jcem-56-5-871
Copyright © 1983 by the Endocrine Society.
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Increase of Neurophysin II Serum Levels in Chronic Alcoholic Patients: Relationship with Alcohol Consumption and Alcoholism Blood Markers during Withdrawal Therapy

J. J. Legros, I. Deconinck, D. Willems, B. Roth, I. Pelc, J. Brauman and M. Verbanck

Neuroendocrinology Section (J.J.L.), CHU, Local 4/12, University of Liege, Sart Tilman, B-4000 Liege, Belgium; and Department of Biological Chemistry (I.D., D.W., J.B.), Metabolic Unit (B.R., M.V.), and Medical Psychology Laboratory (I.P.), Brugmann University Hospital, B-1020 Brussels, Belgium

Address correspondence and requests for reprints to: J. J. Legros, M.D., Neuroendocrinology Section, Centre Hospitalier Universitaire, B23, University of Liege, Sart Tilman, 4000Liege, Belgium.

Neurophysin II (hNpII) but not hNpI serum levels were higher than normal (> 2.85 ng/ml) in 9 of 20 patients admitted to the metabolic ward for alcohol withdrawal therapy; a normalization was observed within the first week of alcohol withdrawal. The higher levels of hNpII were felt to reflect alcohol impregnation for the following reasons: 1) on admission, levels of most of the alcoholism bloodmarkers were higher in the group of patients with high hNpII levels than in the group with normal hNpII levels; 2) hNpII levels were correlated with most of the alcoholism blood markers, mainly {gamma}-glutamyl transpeptidase (r = 0.63, P < 0.001) in the 20 patients of the study; 3) patients with high hNpII levels admitted to greater alcohol and less anxiolytic drug intake immediately before admission.

The physiopathological meaning and hypothetical psychologicalconsequence of this hNpII increase remain to be defined. (J Clin EndocrinolMetab 56: 871, 1983)

Received February 7, 1982.






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Copyright © 1983 by The Endocrine Society