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Journal of Clinical Endocrinology & Metabolism, Vol 56, 871-875, Copyright © 1983 by Endocrine Society

ARTICLES

Increase of neurophysin II serum levels in chronic alcoholic patients: relationship with alcohol consumption and alcoholism blood markers during withdrawal therapy

JJ Legros, I Deconinck, D Willems, B Roth, I Pelc, J Brauman and M Verbanck

Neurophysin II (hNpII) but not hNpI serum levels were higher than normal (greater than 2.85 ng/ml) in 9 of 20 patients admitted to the metabolic ward for alcohol withdrawal therapy; a normalization was observed within the first week of alcohol withdrawal. The higher levels of hNpII were felt to reflect alcohol impregnation for the following reasons: 1) on admission, levels of most of the alcoholism blood markers were higher in the group of patients with high hNpII levels than in the group with normal hNpII levels; 2) hNpII levels were correlated with most of the alcoholism blood markers, mainly gamma- glutamyl transpeptidase (r = 0.63, P less than 0.001) in the 20 patients of the study; 3) patients with high hNpII levels admitted to greater alcohol and less anxiolytic drug intake immediately before admission. The physiopathological meaning and hypothetical psychological consequence of this hNpII increase remain to be defined.




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Copyright © 1983 by The Endocrine Society