This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gundberg, C. M. Articles by Gallop, P. M. Search for Related Content PubMed PubMed Citation Articles by Gundberg, C. M. Articles by Gallop, P. M.

Serum Osteocalcin in the Treatment of Inherited Rickets with 1,25-Dihydroxyvitamin D₃^*

Division of Human Biochemistry and the Department of Orthopaedic Surgery, The Children's Hospital Medical Center, Boston, Massachusetts 02115; the Department of Biological Chemistry, Harvard Medical School and the Department of Oral Biology, Harvard School of Dental Medicine (C.M.G., J.B.L., P.M.G.), Boston, Massachusetts 02115; The DeBelle Laboratory for Biochemical Genetics, McGill University, Montreal Children's Hospital Research Institute (D.E.C.C., T.M.R.), Montreal, Quebec, and the Department of Pediatrics, Dalhousie University, I.W. Killam Hospital for Children (D.E.C.C.), Halifax, Nova Scotia, Canada

Address all correspondence and requests for reprints to: Dr. Caren M. Gundberg, Children's Hospital Medical Center, Enders 1224, 300 Longwood Avenue, Boston, Massachusetts 02115.

Osteocalcin is a vitamin K-dependent protein, synthesized in bone, which can be detected in serum. We have measured circulating osteocalcin levels in 10 patients with xlinked hypophosphatemia (XLH) and in 6 patients with autosomal recessive vitamin D dependence (ARVDD) who started 1,25-dihydroxyvitamin D3 [1,25-(OH)₂D₃] therapy.

Patients with XLH were studied before and after 7–12 months of therapy that included 1,25-(OH)₂D₃ (10–72 ng/kg·day) and oral phosphate. Serum osteocalcin rose from 28 ± 12 to 52 ± 12 ng/ml (mean ± SE; P < 0.01) in concert with improvements in biochemical status and bone mineralization. Vitamin D therapy was withdrawn for 2 weeks from patients with ARVDD. The vitamin D-deplete status was evidenced by low 1,25-(OH)₂D₃ levels (12 ± 2 pg/ml; n = 6). After 1 week of therapy with 1,25-(OH)₂D₃) serum calcium rose from 9.03 ± 0.21 to 9.67 ± 0.25 mg/dl (P < 0.002), while serum phosphorus and alkaline phosphatase remained unchanged. Serum osteocalcin rose from 35 ± 7 to 83 ± 32 ng/ml (P < 0.05). At 3 weeks, serum calcium remained elevated (9.63 ± 0.18 ng/dl) over control levels (P < 0.01); phosphorus and alkaline phosphatase were still unchanged. Serum osteocalcin rose to 114 ± 42 ng/ml, significantly greater than values at 1 week (P < 0.05). Thus, serum osteocalcin increases after 1,25-(OH)₂D₃ therapy in both ARVDD and XLH. (J Clin Endocrinol Metab 56: 1063,1983)

^* Presented in part at the Fifth International Workshop on Vitamin D Metabolism, Williamsburg, VA, February 1982, and at the 54th Annual Meeting of the Society for Pediatric Research, Washington, D.C., May 12, 1982. This work was supported in part by NIH Grants AG-00376 and AM-26333, The Quebec Network of Genetic Medicine, the Medical Research Council of Canada.

Received August 1, 1982.

This article has been cited by other articles:

				T. O. Carpenter, K. C. Moltz, B. Ellis, M. Andreoli, T. L. McCarthy, M. Centrella, D. Bryan, and C. M. Gundberg Osteocalcin Production in Primary Osteoblast Cultures Derived from Normal and Hyp Mice Endocrinology, January 1, 1998; 139(1): 35 - 43. [Abstract] [Full Text] [PDF]

				W. W. K. Koo, R. C. Tsang, J. W. Poser, P. Laskarzewski, D. Buckley, R. Johnson, and J. J. Steichen Elevated Serum Calcium and Osteocalcin Levels From Calcitriol in Preterm Infants: A Prospective Randomized Study Arch Pediatr Adolesc Med, November 1, 1986; 140(11): 1152 - 1158. [Abstract] [PDF]

				M. R. Wilkinson, C. Wagstaffe, L. Delbridge, J. Wiseman, and S. Posen Serum Osteocalcin Concentrations in Paget's Disease of Bone Arch Intern Med, February 1, 1986; 146(2): 268 - 271. [Abstract] [PDF]