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Journal of Clinical Endocrinology & Metabolism, Vol 56, 862-864, Copyright © 1983 by Endocrine Society

ARTICLES

HLA genotyping in family members and patients with familial polycystic ovarian disease

FP Mandel, RJ Chang, B Dupont, MS Pollack, LS Levine, MI New, JK Lu and HL Judd

To determine whether the familial occurrence of polycystic ovarian disease (PCO) is related to the major histocompatibility complex (HLA), four families in whom at least two siblings had clinical evidence of disease were examined. The diagnosis of PCO was confirmed by increased serum testosterone, androstenedione, and LH levels compared to those in normal women. Elevated concentrations of dehydroepiandrosterone sulfate indicated excess adrenal androgen secretion. The result of HLA genotyping in the families studied demonstrate that PCO does not exhibit linkage to the HLA system.


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A. Dunaif
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Endocr. Rev., December 1, 1997; 18(6): 774 - 800.
[Abstract] [Full Text]


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