help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mendelson, W. B.
Right arrow Articles by Gillin, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mendelson, W. B.
Right arrow Articles by Gillin, J. C.

Journal of Clinical Endocrinology & Metabolism, Vol 56, 486-488, Copyright © 1983 by Endocrine Society

ARTICLES

Negative feedback suppression of sleep-related growth hormone secretion

WB Mendelson, LS Jacobs and JC Gillin

Previous studies have demonstrated that injections of growth hormone (GH) can blunt subsequent GH secretory responses to daytime pharmacological stimulation. The current study was undertaken to determine whether GH administration to normal subjects would suppress sleep-related secretion. GH (2 U im) was given nine times over 5 days to each of six subjects, and sleep studies with blood sampling were performed 6 h after the last injection. Secretion during the first 2 h of sleep was decreased by 62.4%, indicating that sleep-related GH secretion may be responsive to a negative-feedback mechanism.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
S. M. Anderson, L. Wideman, J. T. Patrie, A. Weltman, C. Y. Bowers, and J. D. Veldhuis
E2 Supplementation Selectively Relieves GH's Autonegative Feedback on GH-Releasing Peptide-2-Stimulated GH Secretion
J. Clin. Endocrinol. Metab., December 1, 2001; 86(12): 5904 - 5911.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. Spiegel, R. Leproult, E. F. Colecchia, M. L'Hermite-Baleriaux, Z. Nie, G. Copinschi, and E. Van Cauter
Adaptation of the 24-h growth hormone profile to a state of sleep debt
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R874 - R883.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
Y. Hashimoto, T. Kamioka, M. Hosaka, K. Mabuchi, A. Mizuchi, Y. Shimazaki, M. Tsunoo, and T. Tanaka
Exogenous 20K Growth Hormone (GH) Suppresses Endogenous 22K GH Secretion in Normal Men
J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 601 - 606.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1983 by The Endocrine Society