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Journal of Clinical Endocrinology & Metabolism, Vol 55, 810-812, Copyright © 1982 by Endocrine Society

ARTICLES

The effects of corticotropin releasing factor on the anterior pituitary function of stalk-sectioned cynomolgus macaques: dose response of cortisol secretion

HM Schulte, GP Chrousos, EH Oldfield, PW Gold, GB Cutler Jr and DL Loriaux

The recent identification of ovine corticotropin releasing factor (CRF), a 41-amino acid peptide, provides a potential new approach to evaluate disorders of the hypothalamic-pituitary-adrenal axis. We report here the effects of this new factor in the pituitary stalk- sectioned cynomolgus macaque. Given as an intravenous bolus, CRF stimulated cortisol secretion with an ED50 between 0.1 and 1 microgram/kg body weight. The peak cortisol response occurred after 15-- 30 min at low doses (0.5--1 microgram/kg) and after 45--90 min at higher doses (2--40 microgram/kg). This factor also stimulated the release of growth hormone and prolactin, but had no effect on TSH or LH secretion.


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D. Healy, G. Hodgen, H. Schulte, G. Chrousos, D. Loriaux, N. Hall, and A. Goldstein
The thymus-adrenal connection: thymosin has corticotropin-releasing activity in primates
Science, December 23, 1983; 222(4630): 1353 - 1355.
[Abstract] [PDF]


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