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Journal of Clinical Endocrinology & Metabolism, Vol 55, 801-803, Copyright © 1982 by Endocrine Society

ARTICLES

Inhibiton of prostaglandin synthesis by human amniotic fluid: acute reduction in inhibitory activity of amniotic fluid obtained during labor

SA Saeed, DM Strickland, DC Young, A Dang and MD Mitchell

Human amniotic fluid contains an inhibitor of prostaglandin synthesis. The activity of the inhibitor was measured in amniotic fluid obtained in early pregnancy, and at term both before and after the onset of labor. The inhibitory activity was greater in amniotic fluid taken in early pregnancy than in fluid taken at term before the onset of labor (P less than 0.05). There was a further significant reduction in inhibitory activity (P less than 0.01) in amniotic fluid collected during labor. These results are suggestive that the onset of labor is associated with a local withdrawal of inhibition of prostaglandin biosynthesis.


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M. D. Mitchell
Unique Suppression of Prostaglandin H Synthase-2 Expression by Inhibition of Histone Deacetylation, Specifically in Human Amnion but Not Adjacent Choriodecidua
Mol. Biol. Cell, January 1, 2006; 17(1): 549 - 553.
[Abstract] [Full Text] [PDF]

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 ScienceHome page
D. Strickland, S. Saeed, M. Casey, and M. Mitchell
Stimulation of prostaglandin biosynthesis by urine of the human fetus may serve as a trigger for parturition
Science, April 29, 1983; 220(4596): 521 - 522.
[Abstract] [PDF]


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