|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal of Clinical Endocrinology & Metabolism Vol. 55, No. 4 798-800 doi:10.1210/jcem-55-4-798 Copyright © 1982 by the Endocrine Society. SUCCESSFUL FERTILISATION OF HUMAN OOCYTES IN VITRO: CONCENTRATION OF ESTRADIOL-17S, PROGESTERONE AND ANDROSTENEDIONE IN THE ANTRAL FLUID OF DONOR FOLLICLES.11RONALD S. CARSON2, ALAN O. TROUNSON3 and JOHN K. FINDLAYMedical Research Centre, Prince Henry’s Hospital and 3Department of Obstetrics and Gynaecology, Monash University,Queen Victoria Medical Centre Melbourne, Australia. Oocytes and matched samples of follicular fluid were obtained from 156 pre-ovulatory follicles in 125 women 26-36 h after either administration of hCG or the onset of an endogenous LH surge. Concentrations of estradiol- 17β (E2), progesterone (P) and androstenedione (A4) in the fuid of individual donor follicles were measured and related to the success of fertilisation of oocytes in vitro and the incidence of pregnancies after embryo transfer. Oocytes which gave rise to successful pregnancies were obtained from follicles which contained greater concentrations of E2 and a higher ratio of E2 :P than did oocytes from which pregnancy did not result. These data provide direct evidence in support of the hypothesis that estrogenic follicles are the sole source of ova which undergo fertilisation and subsequently give rise to pregnancy in women.
2 2To whom correspondence should be addressed at: Medical Research Centre, Prince Henry’s Hospital, St. Kilda Road, Melbourne, Australia, 3004. 3 2To whom correspondence should be addressed at: Medical Research Centre, Prince Henry’s Hospital, St. Kilda Road, Melbourne, Australia, 3004. Received April 5, 1982. This article has been cited by other articles:
|
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
