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Journal of Clinical Endocrinology & Metabolism, Vol 55, 193-195, Copyright © 1982 by Endocrine Society

ARTICLES

Linkage disequilibrium between insulin-dependent diabetes and the Kidd blood group Jkb allele

J Barbosa, S Rich, T Dunsworth and J Swanson

We studied 102 randomly ascertained probands from the Upper Midwest United States with insulin-dependent diabetes mellitus (IDDM) with respect to both HLA-DR and Kidd (Jk) markers. Based on our evidence that multiple genetic mechanisms may be involved in the etiology of IDDM the data were partitioned according to the HLA-DR phenotype, containing either two high risk antigens (DR3 or DR4) or not. Probands with two such antigens showed no applicable deviation from control frequencies, while the remainder displayed a slightly reduced relative risk for Jka (RR = 0.70, p less than .25), but a significantly elevated risk for Jkb (RR = 2.53, p less than .025). These results strongly suggest a complex model of IDDM inheritance involving, at least, one susceptibility locus in linkage disequilibrium with HLA DR3 and DR4 on chromosome 6, and a second locus in linkage disequilibrium with Jkb on chromosome 2.




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Copyright © 1982 by The Endocrine Society