help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cumming, D. C.
Right arrow Articles by Yen, S. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cumming, D. C.
Right arrow Articles by Yen, S. S.

Journal of Clinical Endocrinology & Metabolism, Vol 54, 1069-1071, Copyright © 1982 by Endocrine Society

ARTICLES

Evidence for an influence of the ovary on circulating dehydroepiandrosterone sulfate levels

DC Cumming, RW Rebar, BR Hopper and SS Yen

Circulating dehydroepiandrosterone sulfate (DS) declines in old age, falling to almost undetectable levels after the seventh decade. Since an accelerated decrease occurs after the menopause, we sought to determine whether ovarian factors may influence adrenal DS secretion independent of chronological age. DS, cortisol, and estradiol levels were compared in subjects grouped according to age, ovarian function, and estrogen replacement. Our data show that premature ovarian failure and ovariectomy in young as well as in postmenopausal subjects precipitate an earlier decline in DS levels. There were no accompanying changes in cortisol levels and no correlations among levels of DS, cortisol, and estradiol. Long term estrogen replacement (over 10 yr) in postmenopausal women over age 65 had no beneficial effect on the age- related DS decline. We suggest that ovarian factors separate from estrogen-mediated effects significantly influence the reduction of DS levels independent of age.


This article has been cited by other articles:


Home page
 DiabetesHome page
K. Dhatariya, M. L. Bigelow, and K. S. Nair
Effect of Dehydroepiandrosterone Replacement on Insulin Sensitivity and Lipids in Hypoadrenal Women
Diabetes, March 1, 2005; 54(3): 765 - 769.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
J. H. Page, G. A. Colditz, N. Rifai, R. L. Barbieri, W. C. Willett, and S. E. Hankinson
Plasma Adrenal Androgens and Risk of Breast Cancer in Premenopausal Women
Cancer Epidemiol. Biomarkers Prev., June 1, 2004; 13(6): 1032 - 1036.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. K. Miller
Androgen Deficiency in Women
J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2395 - 2401.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. A. Laughlin and E. Barrett-Connor
Sexual Dimorphism in the Influence of Advanced Aging on Adrenal Hormone Levels: The Rancho Bernardo Study
J. Clin. Endocrinol. Metab., October 1, 2000; 85(10): 3561 - 3568.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. G. Burger, E. C. Dudley, J. Cui, L. Dennerstein, and J. L. Hopper
A Prospective Longitudinal Study of Serum Testosterone, Dehydroepiandrosterone Sulfate, and Sex Hormone-Binding Globulin Levels through the Menopause Transition
J. Clin. Endocrinol. Metab., August 1, 2000; 85(8): 2832 - 2838.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1982 by The Endocrine Society