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Journal of Clinical Endocrinology & Metabolism, Vol 54, 820-823, Copyright © 1982 by Endocrine Society

ARTICLES

Evidence that chorion-decidual prolactin release is calcium dependent

SR Richards, MH Kim and WB Malarkey

The regulation of PRL release from chorion-decidual explants was evaluated in organ cultures. Agents previously shown to stimulate pituitary release in vitro (TRH, theophylline, estradiol, and vasoactive intestinal polypeptide) were all without effect on chorion- decidual PRL release. Media free of clacium, however, resulted in 44% decreased chorion-decidual PRL release. Conversely, 2.5 mM CaCl2 produced a 64% increase in PRL release (P less than 0.01). Also, calcium chelation with EGTA (0.125-1.0 mM) produced a dose-related decrease in chorion-decidual PRL release. This decrease was greatest at 1.0 mM (P less than 0.01), being 56% of control. In contrast, the calcium-calmodulin complex inhibitor trifluoperazine (10 micrometers) did not significantly alter chorion-decidual PRL release. These studies and previous report in the literature suggest that different control mechanisms govern pituitary and chorion-decidual PRL release; however, an exception appears to be a common role for calcium.




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Copyright © 1982 by The Endocrine Society