| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 54, 459-462, Copyright © 1982 by Endocrine Society
ARTICLES |
NV Bohannon, M Lorenzi, GM Grodsky and JH Karam
The effect of iv tolbutamide on endogenous glucagon levels was measured in nine insulin-dependent diabetic patients chosen because they evidenced no C-peptide response to beta-cell secretagogues. Basal glucagon levels were not suppressed by a sustained tolbutamide infusion; in fact, a slight stimulatory effect was observed at 5, 10, 30, and 45 min. In the absence of detectable insulin secretory capacity and suboptimal insulin replacement, tolbutamide appears to be a stimulus, not a suppressant, of glucagon secretion.
This article has been cited by other articles:
 |
|
 |
|
  I. Quesada, E. Tuduri, C. Ripoll, and A. Nadal Physiology of the pancreatic {alpha}-cell and glucagon secretion: role in glucose homeostasis and diabetes J. Endocrinol., October 1, 2008; 199(1): 5 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gromada, I. Franklin, and C. B. Wollheim {alpha}-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains Endocr. Rev., February 1, 2007; 28(1): 84 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Israelian, N. R. Gosmanov, E. Szoke, M. Schorr, S. Bokhari, P. E. Cryer, J. E. Gerich, and C. Meyer Increasing the Decrement in Insulin Secretion Improves Glucagon Responses to Hypoglycemia in Advanced Type 2 Diabetes Diabetes Care, November 1, 2005; 28(11): 2691 - 2696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. L. Olsen, S. Theander, K. Bokvist, K. Buschard, C. B. Wollheim, and J. Gromada Glucose Stimulates Glucagon Release in Single Rat {alpha}-Cells by Mechanisms that Mirror the Stimulus-Secretion Coupling in {beta}-Cells Endocrinology, November 1, 2005; 146(11): 4861 - 4870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Franklin, J. Gromada, A. Gjinovci, S. Theander, and C. B. Wollheim {beta}-Cell Secretory Products Activate {alpha}-Cell ATP-Dependent Potassium Channels to Inhibit Glucagon Release Diabetes, June 1, 2005; 54(6): 1808 - 1815. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ostergard, K. B. Degn, M.-A. Gall, R. D. Carr, J. D. Veldhuis, M. K. Thomsen, R. A. Rizza, and O. Schmitz The Insulin Secretagogues Glibenclamide and Repaglinide Do Not Influence Growth Hormone Secretion in Humans but Stimulate Glucagon Secretion during Profound Insulin Deficiency J. Clin. Endocrinol. Metab., January 1, 2004; 89(1): 297 - 302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. W.M.T. ter Braak, A. M.M.F. Appelman, I. van der Tweel, D. W. Erkelens, and T. W. van Haeften The Sulfonylurea Glyburide Induces Impairment of Glucagon and Growth Hormone Responses During Mild Insulin-Induced Hypoglycemia Diabetes Care, January 1, 2002; 25(1): 107 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Landstedt-Hallin, U. Adamson, and P.-E. Lins Oral Glibenclamide Suppresses Glucagon Secretion during Insulin-Induced Hypoglycemia in Patients with Type 2 Diabetes J. Clin. Endocrinol. Metab., September 1, 1999; 84(9): 3140 - 3145. [Abstract] [Full Text]
|
|
|
|
|
|
S. R. Peacey, A. Rostami-Hodjegan, E. George, G. T. Tucker, and S. R. Heller The Use of Tolbutamide-Induced Hypoglycemia to Examine the Intraislet Role of Insulin in Mediating Glucagon Release in Normal Humans J. Clin. Endocrinol. Metab., May 1, 1997; 82(5): 1458 - 1461. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
