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*THYROGLOBULIN

Journal of Clinical Endocrinology & Metabolism, Vol 54, 282-285, Copyright © 1982 by Endocrine Society

ARTICLES

A specific plaque-forming cell assay for human thyroglobulin antibody- secreting immunocytes

I Weiss and TF Davies

As the initial step in the investigation of thyroid autoantibody- secreting immunocytes, we have identified such cells in vitro by the use of plaque-forming cell assays dependent on the lysis of antigen- coated sheep red blood cells. Human thyroglobulin antibody-secreting peripheral mononuclear cells were detected in six of seven patients with autoimmune thyroiditis, but not in normal control subjects. Our data indicated that 0.06-1.7% of immunoglobulin-secreting cells have the potential for human thyroglobulin antibody secretion in such patients and validated the specific plaque-forming cell technique for the investigation of thyroid autoantibody production.




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Copyright © 1982 by The Endocrine Society