help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wood, S. M.
Right arrow Articles by Bloom, S. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wood, S. M.
Right arrow Articles by Bloom, S. R.

Journal of Clinical Endocrinology & Metabolism, Vol 53, 1310-1312, Copyright © 1981 by Endocrine Society

ARTICLES

Bombesin, somatostatin and neurotensin-like immunoreactivity in bronchial carcinoma

SM Wood, JR Wood, MA Ghatei, YC Lee, D O'Shaughnessy and SR Bloom

Bombesin, a regulatory peptide found in adult lung and in higher concentration during development in the foetal lung, has potent biological actions which include the ability to stimulate the release of a number of hormones. Radioimmunoassay of extracts of tumour, lung and plasma from patients with bronchial carcinoma revealed very high tissue bombesin concentrations in two oat cell carcinomas, with lower levels in two out of six adenocarcinomas exceeding the concentrations found in normal lung. The oat cell carcinomas also contained significant amounts of somatostatin and in one case neurotensin. Neurotensin was further detected in two out of seven squamous tumours and three adenocarcinomas. Secretion of regulatory peptides by bronchial carcinomas may account for some of their ill-understood non- metastatic clinical manifestations.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
M. Toy-Miou-Leong, C. L. Cortes, A. Beaudet, W. Rostene, and P. Forgez
Receptor Trafficking via the Perinuclear Recycling Compartment Accompanied by Cell Division Is Necessary for Permanent Neurotensin Cell Sensitization and Leads to Chronic Mitogen-activated Protein Kinase Activation
J. Biol. Chem., March 26, 2004; 279(13): 12636 - 12646.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
J.D. Minna, J.F. Battey, B.J. Brooks, F. Cuttitta, A.F. Gazdar, B.E. Johnson, D.C. Ihde, A.-M. Lebacq-Verheyden, J. Mulshine, M.M. Nau, et al.
Molecular Genetic Analysis Reveals Chromosomal Deletion, Gene Amplification, and Autocrine Growth Factor Production in the Pathogenesis of Human Lung Cancer
Cold Spring Harb Symp Quant Biol, January 1, 1986; 51(0): 843 - 853.
[Abstract] [PDF]

Home page
 ScienceHome page
M. Ruff and C. Pert
Small cell carcinoma of the lung: macrophage-specific antigens suggest hemopoietic stem cell origin
Science, September 7, 1984; 225(4666): 1034 - 1036.
[Abstract] [PDF]

Home page
 ScienceHome page
L. Lazarus, R. DiAugustine, G. Jahnke, and O Hernandez
Physalaemin: an amphibian tachykinin in human lung small-cell carcinoma
Science, January 7, 1983; 219(4580): 79 - 81.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1981 by The Endocrine Society