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Journal of Clinical Endocrinology & Metabolism, Vol 53, 1291-1296, Copyright © 1981 by Endocrine Society

ARTICLES

Leydig cell tumor with gynecomastia: hormonal effects of an estrogen- producing tumor

JP Bercovici, D Tater, S Khoury, JF Charles, J Floch and JP Leroy

A patient with a testicular interstitial cell tumor and gynecomastia is reported. The testicular tumor was capable of aromatizing 8.3% testosterone. Spermatic venous samples taken from the tumor-bearing side had marked elevations of 17 beta-estradiol (E2), progesterone, and 17-hydroxyprogesterone (170 HP). The progesterone to 17OHP and 17OHP to androstene-dione ratios suggested an enzymatic block of 17 alpha- hydroxylase and 17-20 lyase possibly secondary to locally produced E2. The E2 produced by the tumor appeared to suppress gonadotropin secretion. The plasma testosterone and gonadotropin levels rose within 7 days after the removal of tumor, and the gynecomastia began to decrease.


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