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Journal of Clinical Endocrinology & Metabolism, Vol 53, 813-817, Copyright © 1981 by Endocrine Society

ARTICLES

Human cord blood concentrations of thyrotropin, thyroglobulin, and iodothyronines after maternal administration of thyrotropin-releasing hormone

E Roti, A Gnudi, LE Braverman, G Robuschi, R Emanuele, P Bandini, L Benassi, A Pagliani and CH Emerson

TRH or saline was administered to 214 term pregnant women at various time intervals (8-820 min) before delivery. Cord blood (CB) was obtained, and plasma TSH, T4, T3, rT3, and thyroglobulin concentrations were measured by specific RIA. CB TSH was significantly elevated within 20 min after TRH administration and remained elevated for 180 min. CB T3 rose significantly by 60 min and remained elevated for 820 min. CB T4 was significantly increased from 120 to 820 min after TRH administration. There was no significant change in the CB thyroglobulin concentration. These findings demonstrate for the first time that TRH crosses the human placenta, that the fetal pituitary is responsive to TRH, and that endogenous TSH stimulates the fetal thyroid.


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N. Shibusawa, M. Yamada, J. Hirato Tuyoshi Monden, T. Satoh, and M. Mori
Requirement of Thyrotropin-Releasing Hormone for the Postnatal Functions of Pituitary Thyrotrophs: Ontogeny Study of Congenital Tertiary Hypothyroidism in Mice
Mol. Endocrinol., January 1, 2000; 14(1): 137 - 146.
[Abstract] [Full Text]


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