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Journal of Clinical Endocrinology & Metabolism, Vol 53, 654-655, Copyright © 1981 by Endocrine Society
ARTICLES |
D Breyer, P Cvitkovic, Z Skrabalo, O Pedersen and B Rocic
Insulin binding to specific erythrocyte receptors was investigated in group of 25 subjects with Klinefelter's syndrome (47 XXY genotype) and 14 healthy male volunteers. Insulin binding was significantly decreased in Klinefelter subjects (P less than 0.01 at insulin concentrations of 0.051 and 0.136 mmol/liter); however, their fasting glucose concentration was normal (87 +/- 17), and the glucose disappearance rate was slightly increased (2.3 +/- 0.9; P less than 0.2). These data indicated a compensatory, mechanism involved in the glucose metabolism in Klinefelter's syndrome.
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