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Journal of Clinical Endocrinology & Metabolism, Vol 53, 651-653, Copyright © 1981 by Endocrine Society

ARTICLES

Absence of thyroid-stimulating antibody and long acting thyroid stimulator in relatives of Graves' disease patients

K Banovac, M Zakarija, JM McKenzie, A Witte and M Sekso

None of the 76 euthyroid relatives of patients with Graves' disease had detectable LATS in their serum nor was thyroid-stimulating antibody (TSAb), assessed by an increment of cAMP in human thyroid slices, detected in any of the 60 sera tested. Seven of 41 were slightly positive for TSH binding-inhibiting immunoglobulin (TBII). Nineteen of 73 sera were positive (greater than 1:1600) for antibody to thyroid antimicrosomal antigen, of which 4 were also positive (greater than 1:400) for antibody to thyroglobulin; 3 of the 19 had a slightly elevated basal TSH which rose excessively after TRH. Thus, although these euthyroid relatives had evidence of thyroid immunological defects, a thyroid-stimulating antibody was not found.




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Copyright © 1981 by The Endocrine Society