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Journal of Clinical Endocrinology & Metabolism, Vol 53, 641-644, Copyright © 1981 by Endocrine Society

ARTICLES

A human parathyroid carcinoma that produces parathyroid hormone: long term maintenance in tissue culture

RA Pattillo, AC Ruckert, SD Wilson, RO Hussa, RW Gray and J Lemann Jr

Parathyroid carcinoma cells from a pulmonary metastasis of a patient with a serum Ca of 17 mg/dl and an immunoreactive parathyroid hormone (PTH) of 6.4 ng eq bovine (b) PTH/ml (normal 40--400 pg/ml) have been maintained in tissue culture for more than 2 1/2 years. The cells secrete PTH into the culture media that 1) during immunoassay dilutes in parallel to human hyperparathyroid serum, 2) has a molecular weight similar to intact highly purified bPTH, and 3) stimulates bone resorption in a manner that is equivalent and additive to synthetic bPTH-(1--34).




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Copyright © 1981 by The Endocrine Society