help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nagulesparan, M.
Right arrow Articles by Bennett, P. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nagulesparan, M.
Right arrow Articles by Bennett, P. H.

Journal of Clinical Endocrinology & Metabolism, Vol 53, 560-568, Copyright © 1981 by Endocrine Society

ARTICLES

Diminished effect of caloric restriction on control of hyperglycemia with increasing known duration of type II diabetes mellitus

M Nagulesparan, PJ Savage, LJ Bennion, RH Unger and PH Bennett

The effect of weight loss and caloric restriction on plasma glucose concentrations and insulin and glucagon secretion in response to oral and iv glucose and arginine infusions was examined in 8 subjects with type II diabetes mellitus of greater than 5 yr duration (long term diabetes). The findings of this study were compared to previous results in 10 subjects with similar degrees of obesity and fasting hyperglycemia but diabetes of less than 2 yr duration (recent-onset diabetes; fasting plasma glucose, 267 +/- 16.5 mg/dl in long term diabetics and 259 +/- 8.0 mg/dl in recent onset diabetics) and to a control group of 8 similarly obese but nondiabetic subjects. Both diabetic groups had impaired insulin responses on initial and final tests compared to control subjects. Response to dietary therapy was significantly poorer in the diabetics of longer duration (final fasting plasma glucose, 175 +/- 18.9 mg/dl in long term vs. 119 +/- 6.2 mg/dl in recent-onset subjects; P less than 0.01) despite a similar degree of weight loss and duration of diet therapy in the 2 groups. This difference in glucose tolerance occurred despite similar final insulin and glucagon responses in the diabetic groups. Subjects with type II diabetes of long duration appear to have a relatively greater degree of insulin resistance than subjects with more recent onset of the disease.


This article has been cited by other articles:


Home page
 The Diabetes EducatorHome page
C. Carver
Insulin Treatment and the Problem of Weight Gain in Type 2 Diabetes
The Diabetes Educator, November 1, 2006; 32(6): 910 - 917.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
J. W. Anderson, C. W.C. Kendall, and D. J.A. Jenkins
Importance of Weight Management in Type 2 Diabetes: Review with Meta-analysis of Clinical Studies
J. Am. Coll. Nutr., October 1, 2003; 22(5): 331 - 339.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. Uusitupa, V. Lindi, A. Louheranta, T. Salopuro, J. Lindstrom, and J. Tuomilehto
Long-Term Improvement in Insulin Sensitivity by Changing Lifestyles of People with Impaired Glucose Tolerance: 4-Year Results From the Finnish Diabetes Prevention Study
Diabetes, October 1, 2003; 52(10): 2532 - 2538.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1981 by The Endocrine Society