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Inhibitory Effect of the Dopamine Agonist Bromocriptine on the Postcastration Gonadotropin Rise in Women^*

Department of Obstetrics and Gynecology, School of Medicine, University of Pisa, Pisa, Italy

Address requests for reprints to: Dr. Gian Benedetto Melis, Clinica Ostetrica e Ginecologica, Universita di Pisa, Via Roma 35, 56100 Pisa, Italy.

Based or stimulated gonadotropin plasma levels were measured after bilateral ovariectomy in untreated and bromocriptine (BCT)-treated normal women. BCT was orally administered from the 7^th to the 14^th day after ovariectomy at a dose of 3.75 mg/day. BCT significantly (P < 0.05) inhibited LH release, both basally and after LRF stimulation. Plasma FSH levels were also reduced in treated subjects, but this decrease did not reach statistical significance relative to controls. The blunted postcastration gonadotropin rise found with BCT administration suggests that pituitary gonadotropin secretion is, in part, under dopaminergic inhibitory control. (J Clin EndocrinolMetab 53: 530,1981)

^* This work was supported by Consiglio Nazionale Ricerche (CNR), Rome, Italy (Biology of Reproduction Project and Grants 79.01891.04 and 80.00445.04).

Received January 5, 1981.