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*Pheochromocytoma

Journal of Clinical Endocrinology & Metabolism, Vol 53, 213-214, Copyright © 1981 by Endocrine Society

ARTICLES

Presence of dynorphin-like immunoreactivity in pheochromocytomas

T Yoshimasa, K Nakao, S Oki, I Tanaka, Y Nakai and H Imura

Using a highly specific and sensitive radioimmunoassay for dynorphin(1- 13), dynorphin-like immunoreactivity (dynorphin-LI) was detected in two extramedullary pheochromocytomas and a medullary pheochromocytoma. The contents of dynorphin-LI of two extramedullary and a medullary tumors were 9.2, 2.2, and 34.0 pmole/g, respectively. Gel chromatographic studies of tumor extracts on Sephadex G-50 revealed a peak of dynorphin- LI eluting at the same position as dynorphin-LI contaminated in porcine ACTH extract (Sigma) and another portion of dynorphin-LI eluting in a range of molecular weights larger than that of dynorphin-LI in porcine ACTH extract. These results indicate the presence of dynorphin and possibly its precursor peptide(s) in pheochromocytoma.




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Copyright © 1981 by The Endocrine Society