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Immunological Evidence for the Occurrence of Luteinizing Hormone-Releasing Factor and the a-Subunit of Glycoprotein Hormones in Carcinoid Tumors^*

TORSTEN WAHLSTRÖM and MARKKU SEPPÄLÄ

Department of Pathology, University of Helsinki, Helsinki, Finland; and the Department of Reproductive Physiology, St. Bartholomew's Hospital Medical College London, ECl, United Kingdom

Address requests for reprints to: T. Wahlstrom, M.D., Department of Pathology, University of Helsinki, Haartmaninkatu 3, SF-00290 Helsinki 29, Finland.

ABSTRACT. The immunoperoxidase technique was used to identify LRF and glycoprotein hormones or their subunits in 22 carcinoid tumors of various origins. All tumors were positive forboth LRF and the a-subunit, whereas stainings with antisera against the β-subunits of CG, LH, FSH, and TSH were negative. The binding of LRF and the a-subunit within the same malignant tissue raises the possibility of a functional relationship between the two. {J Clin Endocrinol Metab 53: 209, 1981)

^* This work was supported by Grant l-ROl-CA-23809-01 from the NCI, DHEW (to T.W.), and a grant from the Research Council for Medical Sciences, Academy of Finland (to M.S.).

Recipient of a United Kingdom Medical Research CouncilFellowship.

Received August 4, 1980.

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