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Journal of Clinical Endocrinology & Metabolism, Vol 53, 200-202, Copyright © 1981 by Endocrine Society

ARTICLES

False hyperthyrotropinemia induced by heterophilic antibodies against rabbit serum

G Schaison, P Thomopoulos, R Moulias and MC Feinstein

A case of false hyperthyrotropinemia was investigated. The serum of the patient contained heterophilic antibodies against rabbit immunoglobulins secondary to immunization with rabbit serum. Some vaccines against viral or bacterial diseases contain animal serum capable of inducing heterophilic antibodies in man. This technical problem can be prevented by the routine addition of control rabbit serum or immunoglobulins to the TSH RIA.


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