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False Hyperthyrotropinemia Induced by Heterophilic Antibodies against Rabbit Serum

Département d'Endocrinologie, Hopital Bicetre le Kremlin-Bicetre;
U-35, HÔpital Henri-Mondor Creteil;
Laboratoire d'Immunologie, HÔpital de la Pitie Paris;
Fondation de Recherche en Hormonologie Fresnes, France

Address request for reprints to: Prof. Gilbert Schaison, Departement d'Endocrinologie, Hopital Bicetre, 78, rue du General Leclerc, 94270 le Kremlin, Bicetre, France.

A case of false hyperthyrotropinemia was investigated. The serum of the patient contained heterophilic antibodies against rabbit immunoglobulins secondary to immunization with rabbit serum. Some vaccines against viral or bacterial diseases contain animal serum capableof inducing heterophilic antibodies in man. This technical problem can be prevented by the routine addition of control rabbit serum or immunoglobulins to the TSH RIA. (J Clin EndocrinolMetab 53: 200, 1981)

Received August 21, 1980.

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