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Journal of Clinical Endocrinology & Metabolism Vol. 53, No. 1 153-157
doi:10.1210/jcem-53-1-153
Copyright © 1981 by the Endocrine Society.
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Effect of Secretin on Parathyroid Hormone and Calcitonin Secretion*

ROMI SETHI, SUBHASH C. KUKREJA, E. NELSON BOWSER, GARY K. HARGIS and GERALD A. WILLIAMS

Section of Endocrinology, Departments of Medicine and Nuclear Medicine, Veterans Administration West Side Medical Center and University of Illinois College of Medicine Chicago, Illinois 60612

Address requests for reprints to: Gerald A. Williams, M.D., Veterans Administration West Side Medical Center (M.P. 115), P.O. Box 8195, Chicago, Illinois 60680.

The effect of secretin on secretion of parathyroid hormone (PTH) and calcitonin (CT) was evaluated by both in vitro and in vivo techniques.

In in vitro studies with bovine parathyroid tissue, Secretin-Boots caused significant dose-related increases in PTH secretion. In in vitro studies with rat thyroparathyroid tissue, Secretin-Boots caused significant increases in both PTH and CT secretion. Infusion of Secretin-Boots or of synthetic secretin in biologically equivalent doses into rats caused similar increases in secretion of PTH and of CT. Infusion of multiple doses of synthetic secretin revealed a dose-related stimulation of both PTH and CT secretion. Infusion of Secretin-Boots into normal human subjects caused prompt and progressive significant increases in secretion of both PTH and CT, with return to baseline values within 90 min after termination of the infusion. These data suggest that secretin can stimulate hormonal secretion by parathyroid and thyroid C cells and that secretin may play a modulating role in the secretion of both PTH and CT.

* This work was supported by the Medical Research Service of the Veterans Administration

Received November 3, 1980.






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Copyright © 1981 by The Endocrine Society