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Absence of Seasonal Variation in Serum Concentrations of 1,25-Dihydroxyvitamin D Despite a Rise in 25-Hydroxyvitamin D in Summer^*

Departments of Biochemistry and Pediatrics, University of Wisconsin Madison, Wisconsin 53706. The Department of Pediatrics, Montefiore Hospital and Medical Center, The Albert Einstein College of Medicine Cincinnati, Ohio 45226 The Food and Drug Research Laboratories, Food and Drug Administration Cincinnati, Ohio 45226

Address requests for reprints to: Hector F. DeLuca, Department of Biochemistry, 420 Henry Mall, University of Wisconsin, Madison, WI 53706.

The serum concentrations of the vitamin D metabolites 25-hydroxyvitamin D₂ (25OHD₂), 25-hydroxyvitamin D₃ (25OHD₃), and 1,25-dihydroxyvitamin D (calcitriol) have been measured in normal subjects whose ages varied from 18 months to 35 yr. Samples were obtained in all months of the year in order to assess the effects of season on serum concentration. During the months of April to September, 25OHD₃ levels are higher than in the winter months. No seasonal variation in the 25OHD₂ or calcitriol serum concentration was observed. Age-related differences in 25OHD₂ and D₃ concentrations did not exist. The levels of calcitriol are higher in adolescence and increase from 35 ± 19 pg/ml (SD) at 1.5–10 yr of age to 54 ± 21 pg/ml at 10–20 yr of age. In young adults, the levels fall again to 28 ± 16 pg/ml. Accordingly, despite a seasonal variation in the precursor of calcitriol, the levels of this most active metabolite of vitamin D do not change in relation to sunlight exposure. This lack of seasonal variation is further evidence of the tight feedback regulation of calcitriol.

^* This work was supported by NIH Grants AM-14881, AM-19489, and ES-01060–06 from the PHS/DHEW, Food and Drug Administration Contract RFP 223–78225, and NASA Contract NAS9–15580

Received November 28, 1980.

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