help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schwartz, M.
Right arrow Articles by Hensle, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schwartz, M.
Right arrow Articles by Hensle, T.

Journal of Clinical Endocrinology & Metabolism, Vol 53, 123-127, Copyright © 1981 by Endocrine Society


ARTICLES

Male pseudohermaphroditism secondary to an abnormality in Leydig cell differentiation

M Schwartz, J Imperato-McGinley, RE Peterson, G Cooper, PL Morris, M MacGillivray and T Hensle

We present the first case of a prepubertal male with an abnormality in Leydig cell differentiation resulting in male pseudohermaphroditism. There was no plasma androgen response to im administration of hCG. Leydig cells were not apparently by either light or electron microscopy in tissue obtained from a biopsy of the right testis 96 h after the last dose of hCG. In addition, LH-hCG saturation analyses performed on membrane preparations from the testicular tissue revealed no binding. An expanded classification for male pseudohermaphroditism is presented.


This article has been cited by other articles:


Home page
J. Clin. Endocrinol. Metab.Home page
J. W. M. Martens, S. Lumbroso, M. Verhoef-Post, V. Georget, A. Richter-Unruh, M. Szarras-Czapnik, T. E. Romer, H. G. Brunner, A. P. N. Themmen, and Ch. Sultan
Mutant Luteinizing Hormone Receptors in a Compound Heterozygous Patient with Complete Leydig Cell Hypoplasia: Abnormal Processing Causes Signaling Deficiency
J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2506 - 2513.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
A. P. N. Themmen and I. T. Huhtaniemi
Mutations of Gonadotropins and Gonadotropin Receptors: Elucidating the Physiology and Pathophysiology of Pituitary-Gonadal Function
Endocr. Rev., October 1, 2000; 21(5): 551 - 583.
[Abstract] [Full Text]


Home page
J. Clin. Endocrinol. Metab.Home page
J. C. Zenteno, P. Canto, S. Kofman-Alfaro, and J. P. Mendez
Evidence for Genetic Heterogeneity in Male Pseudohermaphroditism due to Leydig Cell Hypoplasia
J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3803 - 3806.
[Abstract] [Full Text] [PDF]


Home page
Mol. Endocrinol.Home page
S.-M. Wu, K. M. Hallermeier, L. Laue, C. Brain, A. C. Berry, D. B. Grant, J. E. Griffin, J. D. Wilson, G. B. Cutler Jr., and W.-Y. Chan
Inactivation of the Luteinizing Hormone/Chorionic Gonadotropin Receptor by an Insertional Mutation in Leydig Cell Hypoplasia
Mol. Endocrinol., November 1, 1998; 12(11): 1651 - 1660.
[Abstract] [Full Text]


Home page
J. Clin. Endocrinol. Metab.Home page
S. S. Stavrou, Y.-S. Zhu, L.-Q. Cai, M. D. Katz, C. Herrera, M. DeFillo-Ricart, and J. Imperato-McGinley
A Novel Mutation of the Human Luteinizing Hormone Receptor in 46XY and 46XX Sisters
J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 2091 - 2098.
[Abstract] [Full Text]


Home page
J. Clin. Endocrinol. Metab.Home page
M. Misrahi, G. Meduri, S. Pissard, C. Bouvattier, I. Beau, H. Loosfelt, A. Jolivet, R. Rappaport, E. Milgrom, and P. Bougneres
Comparison of Immunocytochemical and Molecular Features with the Phenotype in a Case of Incomplete Male Pseudohermaphroditism Associated with a Mutation of the Luteinizing Hormone Receptor
J. Clin. Endocrinol. Metab., July 1, 1997; 82(7): 2159 - 2165.
[Abstract] [Full Text] [PDF]


Home page
NEJMHome page
A. C. Latronico, J. Anasti, I. J.P. Arnhold, R. Rapaport, B. B. Mendonca, W. Bloise, M. Castro, C. Tsigos, and G. P. Chrousos
Testicular and Ovarian Resistance to Luteinizing Hormone Caused by Inactivating Mutations of the Luteinizing Hormone-Receptor Gene
N. Engl. J. Med., February 22, 1996; 334(8): 507 - 512.
[Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1981 by The Endocrine Society