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Division of Endocrinology, Department of Medicine, New York Hospital-Cornell University Medical Center New York, New York 10021 Fertility Laboratory, North Shore University Manhasset, New York 11030 the Department of Pediatrics, St. Josephs Hospital Pater son, New Jersey the Department of Pediatrics, Buffalo Childrens Hospital Buffalo, New York 14222 the Division of Pediatric Urology, Babies Hospital, Columbia Presbyterian Medical Center New York, New York 10032
Address requests for reprints to: Dr. Julianne Imperato-McGinley, Cornell University Medical Center, 1300 York Avenue, New York, New York 10021.
We present the first case of a prepubertal male with an abnormality in Leydig cell differentiation resulting in male pseudohermaphroditism. There was no plasma androgen response to im administration of hCG. Leydig cells were not apparently by either light or electron microscopy in tissue obtained from a biopsy of the right testis 96 h after the last dose of hCG. In addition, LH-hCG saturation analyses performed on membrane preparations from the testicular tissue revealed no binding. An expanded classification for male pseudohermaphroditism is presented.
* This work was supported by USPHS Career Research Award K6- AM 14241 (to R.E.P.), Clinical Investigator Award K08-AM-00615-01 (to J.I.M.), and Research Grant HD-09421 from the NIH.
Received November 18, 1980.
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