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Effects of Thyrotropin-Releasing Hormone and Metoclopramide in Patients with Phenothiazine-Induced Hyperprolactinemia^*

Division of Endocrinology, Department of Medicine, Virginia Commonwealth University, Medical College of Virginia Richmond, Virginia 23298

Address all correspondence and requests for reprints to: Dr. Harvey Lankford, Box 111, MCV Station, Richmond, Virginia 23298.

TRH and metoclopramide tests were performed in 10 female patients with presumed phenothiazine-induced hyperprolactinemia to define the serum PRL response to these agents. Our results show that the serum PRL response to metoclopramide is blunted in most patients with phenothiazineinduced hyperprolactinemia, and the serum PRL response to TRH is exaggerated in most patients during and 3 weeks after stopping phenothiazines.

^* Presented in part at the Southern Society for Clinical Investigation, Regional Meeting, New Orleans, LA, January 15, 1981.

Received August 28, 1980.

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